Pair Name	Noscapine, Docetaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Expression	ABCB1	hsa5243
	Down-regulation	Expression	ABCC1	hsa4363
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Expression	BCL2	hsa596
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
In Vivo Model	The orthotopic TNBC xenograft studies were carried out in female Balb/c Nude Mice. Following suitable acclimation of animals, 1.5 ×10⁶ wild-type and 1.0×10⁶ drug-resistant MDA-MB-231 TNBC cells were re-suspended in 100 µl of phosphate buffer solution (PBS), and implanted in the mammary fat pads using a 27-gauge needle Tumors were allowed to grow unperturbed for 10–14 days.
Result	Chemo-sensitizing effect of Nos followed by DTX regime provide a promising chemotherapeutic strategy and its significant role for the treatment of drug-resistant TNBC.